Amongst the various routes of drug delivery, oral route is perhaps the most preferred to the patient and the clinician alike. Review provides knowledge for the patient who cannot swallow, such as the elderly, stroke victims, bedridden patients, patients affected by renal failure and patients who refuse to swallow such as paediatric, geriatric and psychiatric patients. In this review is a collection of mouth drug delivery that avoid first pass mechanism so it can avoid the drug loss, potent drug use and better therapeutic efficiency with improving the patient compliance. Bypass of the gastrointestinal tract and hepatic portal system, increasing the bioavailability of orally administered drugs that otherwise undergo hepatic first-pass metabolism. In addition the drug is protected from degradation due to pH and digestive enzymes of the middle gastrointestinal tract so patient get idea about this route and how to administer. Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. The mucosa has a rich blood supply and it relatively permeable. The objective of this article is to review oral drug delivery system by discussing the anatomy and physiology of mouth, various roots like buccal, sublingual and forms of various dose like tablet, film, gel, chewing gum as drug delivery in mouth and various method to preparation the dose and its evaluation of dose, drug which use as active substance and its polymer for oral drug delivery.
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